Antithyroid Antibodies and Fertility Outcome in Euthyroid Women Undergoing In-vitro Fertilization: A Clinical Article

The presence of antithyroid antibodies is associated with poor IVF outcomes in euthyroid infertile women. Hence, the objective of our study is to find out the effect of antithyroid antibodies on fertilization rate, implantation rate and clinical pregnancy rate in euthyroid women undergoing IVF. Methods and findings: The study was a prospective cohort study conducted at Maulana Azad Medical College, New Delhi. Eighty one euthyroid patients planned for IVF were recruited and divided into 2 groups depending upon the presence of antithyroid antibodies. All of them went through the standard stimulation protocol. The results were compared using unpaired t-test for quantitative variables and Chi-square/Fisher’s exact test for qualitative variables. The prevalence of antithyroid antibodies was 21% in our study population. The fertilization rate was significantly lower (P<0.05) in women with antithyroid antibodies (66.3% versus 78.9%). However, no statistically significant difference was observed in implantation rate (18.2% versus 26.8%) and clinical pregnancy rate (31.3% versus 39.3%).


Bidya Devi A1*, Sudha P1 and Bidhan CK2

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